The power of Hydroxocobalamin: Optimal absorption of Vitamin B12

In this blog we dive deeper into the topic of vitamin B12, with a special focus on hydroxocobalamin and its absorbability. Earlier we wrote about vitamin B12 in general.

Different forms of vitamin B12

At Golden Naturals, we use three different natural forms of vitamin B12 in our products: methylcobalamin, adenosylcobalamin, and hydroxocobalamin. We consciously choose not to use the synthetic form, cyanocobalamin. Methylcobalamin and adenosylcobalamin are biologically active forms, which means that the body no longer needs to convert them and can immediately get to work with the active substance. Hydroxocobalamin is best known from injections and is one of three natural forms alongside methylcobalamin and adenosylcobalamin.

What is Hydroxocobalamin?

Hydroxocobalamin is first converted to methylcobalamin and then to adenosylcobalamin. The latter form mainly plays a role in the mitochondria, the energy factories of the cell. Hydroxocobalamin has the longest half-life in the body, while adenosylcobalamin and methylcobalamin have a shorter half-life of up to 6 hours. This combination of three forms of vitamin B12 makes it the ultimate B12 supplement as a lozenge.

Absorbability of hydroxocobalamin

Hydroxocobalamin is not commonly used in vitamin B12 supplements because it is less absorbable in tablet or capsule form that you swallow. An intrinsic factor is needed for absorption, together with gastric juice and the enzyme pepsin. In the case of oral or lozenges, this intrinsic factor is not necessary, because the ingredients are absorbed through the mucous membranes in the mouth. This means that hydroxocobalamin is indeed absorbed, but it must be taken via a melt or lozenge.

With hydroxocobalamin in combination with the two other biologically active forms, methylcobalamin and adenosylcobalamin, Golden Naturals has introduced a unique melting tablet with excellent absorption.

Questions or more information?

Do you have questions or would you like more information? We can be reached during opening hours on 0499-440222 or via chat. The chat function can be found at the bottom right of the page.